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ID:3005 Combination of vaccine-strain measles and mumps viruses enhances oncolytic activity against human solid malignancies: special focus on prostate cancer

Toan Linh Nguyen 1, *
Ho Anh Son 1
LiFeng Zhang 2
Bui Khac Cuong 3
Hoang Van Tong 3
Le Duy Cuong 3
Hoang Thi My Nhung 3
Naoki Yamamoto 4
  1. Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam
  2. Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  3. 1Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam
  4. 2Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Correspondence to: Toan Linh Nguyen, Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam. Email: [email protected].

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Copyright The Author(s) 2024. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

Oncolytic viruses (OLVs) including measles and mumps viruses (MeV and MuV) have a potential to serve as a therapeutic option for cancers. We have previously shown that the combination of MeV and MuV synergistically kills various human haematological cancer cells. This study aims to investigate the anti-tumor activity of MeV, MuV and MeV-MuV combination (MM) against human solid malignancies in vitro and in vivo. The results showed that MeV, MuV and MM combination targeted and effectively killed various cancer cell lines of human solid malignancies but not normal cells. Notably, MM combination demonstrated a greater anti-tumor effect and prolonged survival in a human prostate cancer (PC3) xenograft tumour model compared to MeV and MuV. MeV, MuV and MM combination significantly induced the expression of immunogenic cell death (ICD) markers and enhanced spleen-infiltrating immune cells such as macrophages, natural killer and dendritic cells. Our study demonstrated that MM combination is a promising option for treatment of human solid malignancies and suggested that MM could induce immunogenic cell death of malignant cells and activate immunity against cancers.

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