Poster Abstract
ID: 1031 Synthesis of Polymeric Nanoparticles of α-mangostin and its Cytotoxicity to Human Cancer Cell Lines
- Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam
Correspondence to:
Phuong T.M. Nguyen,
Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam.
Email:
[email protected].
Volume & Issue:
Vol. 4 No. S (2017): Abstract Proceeding: International conference INNOVATIONS IN CANCER RESEARCH AND REGENERATIVE MEDICINE 2017
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Page No.:
S 106
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DOI:
10.15419/bmrat.v4iS.307
Published:
2017-08-31
Abstract
α-Mangostin (AMG) extracted from Garcinia mangostana L., has potent anti-cancer properties, however its clinical application is limited due to poor aqueous-solubility. Here, we successfully synthesised and characterised water-soluble ß-cyclodextrin-coated AMG 30-50 nm-size nanoparticles (NMG). Similar cytotoxic activities against LU-1 (human lung adenocarcinoma) and HL-60 (human promyelocytic leukemia) cancer cells of water-soluble NMG and organic-solvent soluble AMG were found with IC50 of 8.86 and 9.86 µg/mL, respectively. The data demonstrates that the nanoparticles improve bioavailability while maintain anti-cancer activity of AMG.