journal description

 

Biomedical Research and Therapy - Vietnamese Journal for Medical Biotechnology and Medicine Incorporating Advances in Regenerative Medicine publishes 12 peer-reviewed issues each year, covering a wide range of biomedical and clinical sciences. Unlike many open-access journals, which charge authors for publication while providing free reader access, Biomedical Research and Therapy does not require fees for subscription, submission, processing, publication, or color image reproduction. Recognized internationally, this journal is committed to disseminating high-quality research in an open-access format, emphasizing basic, translational, and clinical studies on molecular therapeutics and cellular therapies. It includes research involving animal models and clinical trials. The rigorous peer-review process ensures that only scientifically, technically, and ethically sound articles adhering to standard reporting guidelines are published. The journal’s editorial policies are in strict alignment with standards set by the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE), upholding the highest principles of publication ethics.

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latest articles

Original Research

Contriving a multi-epitope vaccine against African swine fever utilizing immunoinformatics

by Fagbohun O., Aiki-Raji C., Omotosho O., Akinniyi O., Jarikre T., Emikpe B.

Summary: African swine fever virus (ASFV) causes African swine fever, a highly fatal hemorrhagic viral disease of domestic swine, severely impacting the development of swine industries in affected countries. The management of this disease is significantly hindered by the absence of protective vaccines against the virus. A cost-effective approach to developing potent vaccines is by employing immunoinformatic tools to identify highly conserved IFN-g , CD4+, CD8+, and B-cell epitopes. These can then be combined to create a multi-epitope broad-spectrum vaccine.

Case report

Synchronous occurrence of Retroperitoneal Pleomorphic Liposarcoma and Papillary thyroid carcinoma: A Rare Case Report

by Yeduguri J., Raju K., Khattepur A., Nattiala N., Balaji N., Kolkar P.

Summary: Pleomorphic liposarcoma is one of the rarest malignancies. In this case report, we present a primary pleomorphic liposarcoma of the retroperitoneal cavity in a 73-year-old male patient.

Original Research

3-strain novel combinatorial probiotic formulation has a prophylactic role in maintaining intestinal barrier function via a reparative modulation of alkaline phosphatase in a pre-clinical inflammatory bowel disease

by Biswas S., Mitra S., Dutta R., Banerjee E.

Summary: Oxidative stress is a significant issue arising from the excessive production of oxidants by superoxide oxides and nitric oxides in our body, which leads to inflammation and tissue damage. In patients with inflammatory bowel disease (IBD), the immune system mistakenly identifies food as antigens, releasing various cytokines to combat this perceived threat and causing IBD symptoms. The loss of intestinal barrier integrity is directly linked to the severity of IBD. It results in a leaky gut, bacterial infiltration, and an increase in inflammatory cytokines. The immune system typically combats infections through the generation of various T- and B-lymphocytes, leading to an adaptive immune response.

Original Research

Efficient isolation of mesenchymal stem cells from amniotic fluid via a two-step culture method

by Hoseini S., Kalantar S., Zarein F., Sadeghian F., Ghasemi-Esmailabad S., Hajimaghsoudi E., Montazeri F.

Summary: The acquisition of human mesenchymal stromal/stem cells (hMSCs) is imperative for therapeutic interventions. These versatile cells can be sourced from various fetal tissues often regarded as medical waste post-delivery. Fetal hMSCs are also procurable from aborted fetuses during the initial and early second trimesters, and amniotic fluid (hAF-MSCs) secured through amniocentesis aimed at prenatal diagnostics. This study endeavors to evaluate two economical strategies for isolating hAF-MSCs: the one-step and the two-step method, emphasizing their efficiency and potential applications in cell therapy and regenerative medicine.

Review

Target receptors in diabetic neuropathy: Key insights & implications

by Sharma G., . B., Akhtar J., Khan M., Ahmad M., Neopane D.

Summary: Diabetic neuropathy (DN) is a debilitating complication of diabetes mellitus (DM), characterized by nerve damage resulting from chronic hyperglycemia. This condition affects a significant proportion of diabetic patients, leading to symptoms such as weakness, numbness, and pain, particularly in the extremities. The pathogenesis of DN is complex and involves metabolic, vascular, and neurotrophic factors. At the core of its development are various receptors that mediate and modulate the underlying biochemical and cellular processes. Key receptors implicated in DN include the advanced glycation end-product receptor (RAGE), which is involved in oxidative stress and inflammation. Additionally, transient receptor potential channels, namely TRP channels, particularly TRPV1 and TRPA1, play an important role in the sensation of pain and thermal stimuli, contributing to the sensory abnormalities observed in DN. Insulin and insulin-like growth factor receptors also play significant roles, as insulin signaling is crucial for neuronal survival and function. Furthermore, purinergic receptors, specifically the P2X and P2Y subtypes, are involved in neuroinflammation and pain transmission. Understanding the roles and interactions of these receptors provides valuable insights into the pathophysiology of DN and highlights potential therapeutic targets. Future research focusing on modulating these receptor pathways holds promise for developing effective treatments to alleviate symptoms and potentially reverse the progression of DN.

Review

Update on the use of platelet-rich plasma in the treatment of osteoarthritis: New supporting evidence

by Do-Minh N., Nguyen-Trong H., Vu-Bich N., Pham-Van P.

Summary: Platelet-rich plasma (PRP) therapy has gained popularity as a treatment option for osteoarthritis, despite a lack of formal endorsement by professional associations. While not universally recommended, its application in managing joint osteoarthritis and aiding ligament regeneration has received approval in several countries. Research into PRP's effectiveness in treating joint osteoarthritis presents promising outcomes, but suffers from inconsistencies across various studies. These disparities stem from differences in the methods of PRP preparation, the concentration of platelets, the frequency of injections, and the specific type of PRP utilized. This article aims to provide the most recent insights into the efficacy of PRP therapy for joint osteoarthritis, underscoring the significant impact of PRP classification, platelet dosage, and injection regimen on therapeutic outcomes. In sum, findings from this study advocate for the use of PRP in managing joint osteoarthritis, highlighting its potential benefits when applied under optimized conditions.

Letter to Editor

Gut microbiome influences incidence and outcomes of breast cancer by regulating levels and activity of steroid hormones in women

by Pathoor N., N., Ganesh P. S.

Summary: This review comprehensively examines the role of the gut microbiome in breast cancer by regulating steroid hormones, emphasizing the impact of probiotics on gut diversity and metabolic health. The discussion could be enriched with more detailed mechanistic insights and longitudinal studies.

Case report

Renal failure in a pediatric patient secondary to HCoV-NL63 infection: A case report

by Kori A., M., M., Ibrahim K., Jalil N., A., C., Ilias M. I.

Summary: Coronaviruses (CoVs) are members of the Nidovirales family, Coronaviridae. To date, seven human CoVs have been identified, some of which are known to circulate persistently in the human population, particularly among young infants. Among these CoV types, renal disease is a recognized complication associated with SARS-CoV-2. No cases of renal disease caused by HCoVNL63 have been reported.

Original Research

Nutritional Status, Dietary Patterns, and Prealbumin as Prognostic Factors in Stroke: An Observational Study

by Koç A., Ersoy A.

Summary: Prealbumin is a protein synthesized by the choroid plexus and liver, playing integral roles in the transport of thyroxine and retinol. Its serum levels are known to decrease in response to conditions such as inflammation, protein deficiency, end-stage liver disease, and malignancy. Notably, decreased serum prealbumin levels have been negatively correlated with the severity of stroke. Given this context, understanding factors that predict functional outcomes and mortality in stroke patients is crucial, particularly the potential role of nutritional status and prealbumin levels.

Case report

Simple-Virilizing Congenital adrenal hyperplasia sustained by five mutations on the CYP21A2 gene

by Agrimonti G., Spaggiari G., Menabò S., Vezzani S., Magnani E., Frasoldati A., Granata A., Santi D.

Summary: Classical congenital adrenal hyperplasia is a genetic disorder characterized by defects in the steroidogenesis cascade, mainly due to 21-hydroxylase enzyme deficiency. The phenotype can vary from the most severe salt-wasting syndrome to the less severe simple-virilizing form. The genotype-phenotype correlation is complex, and it is expected that the higher the number of mutations detected, the worse the phenotype would be. Moreover, when more than one mutation occurs in the same patient, the phenotype should be the result of the most severe mutation detected.

Original Research

Association study between polymorphisms within MPPED2 (rs12797813), MTR (rs61739582), ACTN2 (rs6656267) and LPO (rs7209537) genes and susceptibility to dental caries: a case-control study

by Akbarian S., Daneshmehr S., Nazari Y., Kobravi S., Fetrati A., Amin M., R., Biglak B., Alizadeh F.

Summary: The linkage between specific genetic variants and the susceptibility to dental caries remains a crucial area of investigation. This study aimed to examine the association of particular gene variants within MPPED2 (rs12797813), MTR (rs61739582), ACTN2 (rs6656267), and LPO (rs7209537) genes with the likelihood of developing dental caries.

Review

Association between blood Interleukin-10 level in coronary artery disease: A systematic review, meta-analysis, and network analyses

by Moghadam R., Rouzbahani M., Salehi N., Sadeghi M.

Summary: Cytokines can be key factors in the pathogenesis of coronary artery disease (CAD). This systematic review and meta-analysis aimed to assess the levels of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the serum/plasma of patients with CAD.

Original Research

Comparative Efficacy of CNV-Sequencing and Karyotyping in Prenatal Genetic Diagnosis

by Tang H., X., Pham H., V., Nguyen C., X., Nguyen H., T., Luu H. T.

Summary: This study aimed to compare the efficacy of Copy Number Variation sequencing (CNV-Seq) with that of traditional karyotyping in prenatal diagnostics by assessing their concordance and ability to identify aneuploidies and structural abnormalities in fetal chromosomes.

Original Research

CellTravel: An injectable, defined medium for cool or ambient temperature transport and short-term storage of human mesenchymal stem cells

by Kiet P., T., Trang N., T., H., Phat N., T., Ngoc V., B., Phuc P. V.

Summary: Mesenchymal stem cells (MSCs) are increasingly used for the treatment of various diseases. However, the treatment cost remains relatively high. One reason for this is the complexity and expense involved in the transportation and use of MSCs. Currently, most of the transport of stem cells from the production site to the hospital is carried out under cold conditions with CO2 ice or liquid nitrogen. This transportation is difficult and costly, especially from one country to another. At the site of use, the use of products is also complicated, requiring cells to be properly thawed and sometimes washed to remove cold storage medium before use. Therefore, this study aimed to investigate the transport and storage medium of MSCs at room and cool temperature (2-8 oC).


 

 

Journal Collections

Covid-19 publications
The collections of Covid-19 related articles published by Biomedical Research and Therapy
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Journal Supplements

Conference Abstracts
The collections of abstract book were published by Biomedical Research and Therapy
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Journal Collections

 

Stem Cells and Regenerative Medicine
The collections of published articles about stem cells as well as regenerative medicine. 
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Special Issues 

Special Issues 
Biomedical Research and Therapy would like to invite guest editors to contribute special issue. 
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Journal Collections

Natural Extract
The collections of published articles about herbal, natural products. 
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Publication Awards

The best original research articles
Every year, all authors published their studies as Original research in Biomedical Research and Therapy can join this awards.
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Editors' quote

 


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.
 
 

Affiliation

Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.
 
 
 

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