journal description


Biomedical Research and Therapy - Vietnamese Journal for Medical Biotechnology and Medicine Incorporating Advances in Regenerative Medicine publishes 12 peer-reviewed issues each year, covering a wide range of biomedical and clinical sciences. Unlike many open-access journals, which charge authors for publication while providing free reader access, Biomedical Research and Therapy does not require fees for subscription, submission, processing, publication, or color image reproduction. Recognized internationally, this journal is committed to disseminating high-quality research in an open-access format, emphasizing basic, translational, and clinical studies on molecular therapeutics and cellular therapies. It includes research involving animal models and clinical trials. The rigorous peer-review process ensures that only scientifically, technically, and ethically sound articles adhering to standard reporting guidelines are published. The journal’s editorial policies are in strict alignment with standards set by the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE), upholding the highest principles of publication ethics.

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latest articles


Study on gene expression of IL-17A in eutopic and ectopic tissue sample of endometriosis patients and comparison with control group

by Hoseininasab F., Mehrjardi Y., V., Javaheri A., Tajamolian M., Samadi M.

Summary: The growth of endometrial tissue beyond the uterine cavity characterizes endometriosis, a chronic inflammatory disease. IL-17A, along with other immune mediators and a myriad of immune cells including Th17 lymphocytes and macrophages, are more prevalent in the peritoneal fluid of patients with endometriosis. IL–17A facilitates the implantation of endometrial tissue in ectopic locations by inducing growth factors and inflammatory cytokines from other immune cells. This work focuses on the levels of IL-17A gene expression in tissue samples from patient and control groups, as prior research has not extensively covered the gene expression of inflammatory mediators in tissue samples.


The value of hematological indices as predictors of septic shock in acute obstructive pyelonephritis

by Truong M., H., Ngo T., Q., Nguyen Q., T., To P., T., Tran P., T., Le H. D.

Summary: Acute Obstructive Pyelonephritis (AOP) is a severe and prevalent infection within the urinary system, prone to rapidly escalate into urosepsis and potentially result in septic shock, which poses a significant mortality risk. This study investigates the potential of certain blood parameters to serve as indicators for predicting the likelihood of developing septic shock in AOP patients.

Original Research

Exploring the Effect of Phytochemical Extract (Benincasa sp.) on the Inflammatory Mediators and Regulatory Pathways of Acute Cisplatin Nephrotoxicity in Pre-clinical Mouse Model

by Pal P., Banerjee E. R.

Summary: Cisplatin-induced acute nephrotoxicity is typically manifested by a decrease in kidney function, electrolyte imbalances, and acute kidney injury (AKI). Most therapies for AKI are costly and have serious side effects. Utilizing phytotherapy for the prevention of kidney disease has the potential to reduce both treatment expenses and the occurrence of associated side effects. Benincasa cerifera (BC) offers extensive advantages owing to its anti-inflammatory, antioxidant, and anti-diabetic characteristics. This study aims to demonstrate the protective effects of BC on the inflammatory mediators and regulatory pathways in a cisplatin-induced acute kidney injury (AKI) model.

Original Research

Significant Associations Between Age, Menstrual Status, and Histopathological Types of Cervical Carcinoma in Vietnamese Patients: Insights from a Retrospective and Prospective Analysis

by Pham H., V., Phan V., M., Bui C., V., Nguyen T., A., Luu H., T., Tran T., H., Tang H. X.

Summary: Cervical cancer, predominantly associated with high-risk Human Papillomavirus (HPV) types 16 and 18, presents a substantial public health challenge, particularly impacting women in low and middle-income countries. This study aims to address a vital knowledge gap by examining the relationship between age, menstrual status, and histopathological types of cervical carcinoma in Vietnamese patients.

Case report

Eosinophilic Gastrointestinal Disease Presenting as Chronic Diarrhea: A Case Report

by Phan N., T., Ho P., T., Ma N., P., Pham T., Q., Quach D. T.

Summary: Eosinophilic gastrointestinal diseases (EGIDs) constitute a spectrum of disorders distinguished by the abnormal infiltration of eosinophils into the walls of the gastrointestinal tract, a phenomenon that frequently results in delayed or overlooked diagnoses due to the nonspecific nature of symptoms and endoscopic findings. This article discusses a noteworthy case characterized by chronic diarrhea and mild abdominal discomfort. The presence of peripheral eosinophilia and the evidence obtained from biopsies raised suspicions, ultimately leading to the diagnosis of EGIDs. Despite a two-month diagnostic delay attributed to limited disease awareness, the patient responded well to medical management. The therapeutic regimen comprised methylprednisolone, ketotifen, and montelukast, complemented by dietary modifications, culminating in the full resolution of symptoms. A notable complication was the onset of severe cellulitis during steroid treatment, necessitating an expedited reduction in the steroid dosage while continuing with other medications and undertaking surgical debridement. This infection was successfully controlled, and the corticosteroid therapy was gradually tapered off and discontinued over an eight-week period. The administration of ketotifen and montelukast was maintained, with no further recurrences reported. This case exemplifies the critical need to consider EGIDs in the differential diagnosis of individuals presenting with gastrointestinal symptoms, particularly when peripheral eosinophilia is evident. Furthermore, it emphasizes the imperative of holistic patient care, inclusive of managing infectious complications that may arise during the course of treatment.

Case report

A novel KIF11 missense mutation causing Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR): A case report and literature review

by Asadollahi S., Sefid F., Askari M., Mohammadi S., A., Jahantigh H., R., Ordooei M.

Summary: Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) is an autosomal dominant rare syndrome. The characteristic features include microcephaly, eye disorders, and mild-to-moderate intellectual disability. Recent evidence has revealed that mutations in the kinesin family member 11 (KIF11) gene are associated with MCLMR.

Original Research

Methanol extract from Apium graveolens stimulate glucagon-like peptide-1 secretion (GLP-1), reduced dipeptidyl-peptidase-4 (DPP-4) and protect pancreatic b cells against glucotoxicity and H2O2 toxicity

by Gutiérrez R., M., Pér., Flores J.é M.ía M.

Summary: Glucagon-like peptide-1 (GLP-1) plays a critical role in glucose regulation by stimulating insulin secretion in a glucose-dependent manner. It enhances the functionality of pancreatic β-cells, minimizing apoptotic signals while promoting their proliferation and neogenesis. Consequently, leveraging plant-based GLP-1 agonists offers a promising approach to mitigating hyperglycemia in individuals with type 2 diabetes. This study aimed to explore the potential of methanol extract from Apium graveolens (commonly known as celery) to enhance insulin secretion, inhibit dipeptidyl peptidase-4 (DPP-4), and boost GLP-1 levels. Furthermore, it assessed celery's ability to protect pancreatic β cells against glucotoxicity and H2O2-induced toxicity in vitro. Additionally, we sought to identify the flavonoids present in the crude ethanolic extract of celery through HPLC/MS analysis.

Original Research

In silico identification and gene expression of miR-148a-5p and IL-6 in hypothyroid patient blood samples

by Suthagar P., Puthiya Purayil A., S., U., Parambath A., K., Sekar D.

Summary: Hypothyroidism, marked by a deficiency in thyroid hormone levels, is a common condition with varying clinical presentations. The diagnosis primarily relies on statistical reference ranges of biochemical parameters, which remains a topic of contention. While manageable, untreated cases can lead to serious consequences. MicroRNAs, small non-coding RNAs, have been implicated in hypothyroidism and other diseases, underscoring their significant role in pathophysiology.

Original Research

Effects of Imiquimod Application Durations on Psoriasis-like Lesions and Cytokine Expression in Mice

by Tran P., Le L., Le T., Van T., Vu N.

Summary: Psoriasis is a chronic inflammatory skin disorder with a complex pathogenesis, prominently involving the IL-17/IL-23 pathway. The imiquimod (IMQ)-induced mouse model is widely utilized for preclinical psoriasis research. This study aims to elucidate the effects of different durations of IMQ exposure on the development and characteristics of psoriasis-like lesions and the underlying changes of related cytokines in mice.

Original Research

Development of a 3D-printed negative pressure cutter for precise apical resection in neonatal mouse hearts

by Le M.,-T., Pham T.,-T.,-H., Le T.,-H., Phan Q.,-H., Vo V.,-T., Le N.-B.

Summary: The cardiac cells of neonatal mice, only one day old, exhibit ongoing cell cycle activity for a duration of 14 days following parturition. Their hearts have a strong capacity to replace cardiomyocytes, which disappears in adulthood, in order to respond to injuries sustained during that time. Numerous studies have been conducted to examine the intrinsic regenerative capacity of neonatal mice's hearts following a resection of 1 millimeter from the ventricular apex. However, it should be noted that there is currently a lack of specialized cutting tools designed specifically for this particular field of research. This absence of appropriate instruments may result in challenges when attempting to achieve consistent sample cuts, as human error can introduce variability. Furthermore, it is important to acknowledge that larger cuts may pose a significant risk to the subject's life.


Correlation of Chemotherapy and Radiation Therapy with Atypical Oral Cellular Changes: A Cytological Study in Cancer Patients

by Abdelmoneim I., Idris A. A. A.

Summary: Oral cancer is a prevalent global health issue, with chemotherapy and radiation therapy commonly used in its treatment.


Platelet reactivity in patients with coronary artery disease undergoing dual antiplatelet therapy with aspirin and clopidogrel

by Nguyen N., Nguyen M.

Summary: Dual antiplatelet therapy (DAPT), incorporating aspirin and a P2Y12 receptor inhibitor, is advised for patients experiencing acute coronary syndrome and for those with coronary artery stents, aiming to mitigate the risk of cardiac events attributable to thromboses. Nevertheless, the therapeutic challenge lies within the narrow therapeutic window where either excessive or deficient platelet reactivity (PR) during DAPT can predispose to thrombotic events or hemorrhage, respectively. This underscores the criticality of attaining an optimal PR level throughout the course of therapy. Accordingly, this study was conducted to evaluate PR among Vietnamese patients administered with DAPT, examining the implications for coronary artery disease management. This study aimed to evaluate PR in the context of aspirin therapy, utilizing the VerifyNow system, and to evaluate PR in the context of clopidogrel therapy, also utilizing the VerifyNow system.


Association between Ag-NOR dots and immunohistochemical markers in different grades of breast ductal carcinoma

by Fadil T., M., A., Ellaithi M., M., H., Idris A. A. A.

Summary: Breast cancer is recognized as a significant health issue in developed countries.

Case report

Acquired Platelet Dysfunction with Eosinophilia: A Case Series

by Saidin N., I., S., Min F., A., N., Zulkafli Z., Rahman W., S., W., A., Iberahim S., Hassan M., N., Noor N. H. M.

Summary: Acquired platelet dysfunction with eosinophilia (APDE) is characterized by a temporary impairment in platelet function accompanied by significant eosinophilia. This condition, also known as "non-thrombocytopenic purpura with eosinophilia," primarily affects children in the South-East Asian region, presenting as a bleeding disorder.



Journal Collections

Covid-19 publications
The collections of Covid-19 related articles published by Biomedical Research and Therapy
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Journal Supplements

Conference Abstracts
The collections of abstract book were published by Biomedical Research and Therapy
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Journal Collections


Stem Cells and Regenerative Medicine
The collections of published articles about stem cells as well as regenerative medicine. 
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Special Issues 

Special Issues 
Biomedical Research and Therapy would like to invite guest editors to contribute special issue. 
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Journal Collections

Natural Extract
The collections of published articles about herbal, natural products. 
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Publication Awards

The best original research articles
Every year, all authors published their studies as Original research in Biomedical Research and Therapy can join this awards.
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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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