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latest articles
Primary evaluation the effects of Boesenbergia pandurata ethanol extract on etoposide-induced senescence in fibroblasts
by Vo
P.,
Do
N.,
Nguyen
S.
Summary: Cellular senescence is an extensively researched issue aimed at influencing the aging process. A novel research direction involves studying the potential of plant extracts on this process. Boesenbergia pandurata (Roxb.) Schltr, also known as Boesenbergia rotunda (L.) Mansf, is a herb with significant potential for research into its effects on aging. Furthermore, it is crucial to study cellular senescence models to accurately assess the impact of various agents on the aging process.
The relationship between MBL2 levels and NLRP3 in acute ischemic stroke: Insights from a proteomics study
by Zhu
B.,
Li
X.,
Tian
Y.,
Yang
H.,
Wu
M.,
Wang
S.,
Wang
B.,
Zhao
Z.
Summary: Inflammation plays a pivotal role in the pathogenesis of stroke. However, the proteins that initiate inflammatory responses remain unclear. In this study, we utilize proteomics to identify the core protein in acute ischemic stroke (AIS) patients and verify the relationship of the protein with NOD-like receptor protein 3 (NLRP3).
Hemocyanin is a major allergen in local mud crab Scylla paramamosain in Viet Nam
by Le
K.,-M.,
Trinh
H., K., T.,
Van
T., N., V.,
Pham
D., L.,
Nguyen
H., T.,
Tran
T.,-T.,
Thi
M., N., T.,
Pham
B., Y.,
Pham
D. M.
Summary: Shellfish allergy is prevalent in coastal countries across Asia. Despite crab being a popular dish, there is limited knowledge about the features of crab allergy in Viet Nam. This study aims to identify the IgE-binding allergens in the local crab species, Scylla paramamosain (S. paramamosain).
Platelet-rich plasma therapy for meibomian gland dysfunction and dry eye: A mini review
by Nguyen
S.,
Pham
P.
Summary: A common eye condition known as dry eye syndrome is characterized by insufficient tear production or rapid tear evaporation, causing dryness, irritation, and pain. A common etiological cause for dry eye disease (DED) that affects both the composition and production of tears is meibomian gland dysfunction (MGD). Meibum, an oily substance produced by the meibomian glands, is essential for preventing tear evaporation. The temporary alleviation offered by standard dry eye therapies has prompted researchers to investigate new therapeutic modalities. Platelet-rich plasma (PRP) therapy has been identified as a viable approach for stimulating meibomian gland activity and improving tear production in dry eye patients. Highly concentrated platelets and growth factors found in PRP are essential for promoting tissue regeneration and accelerating the healing process. By the application or injection of PRP in the affected region, the growth factors could stimulate the production and release of meibum, thereby improving the functionality of the meibomian glands and reinstating the stability of the tear film. The objective of this review article is to conduct a comprehensive analysis of clinical evidence supporting the utilization of PRP therapy in managing MGD and dry eye syndrome. Several studies have demonstrated the efficacy of PRP therapy in enhancing meibomian gland function, mitigating ocular surface inflammation, and alleviating symptoms associated with dry eye. Based on the research outcomes, it has been determined that PRP therapy exhibits potential efficacy as a novel intervention for treating dry eye syndrome. This therapeutic approach demonstrates the ability to enhance the health of the ocular surface and target the fundamental etiological factors associated with this condition. Additional research and investigation are required to ascertain the optimal protocols and long-term efficacy of PRP therapy in treating dry eye and MGD. In conclusion, PRP therapy represents a promising and effective treatment option for patients suffering from dry eye syndrome and MGD, offering significant improvements in ocular surface health and patient quality of life.
Three-dimensional culture model of urothelial carcinoma cell lines: current advances, challenges and future perspective
by Mansor
S.,
Syafiq
T.,
Yahaya
B.
Summary: Despite the high number of cases reported, studies describing the pathogenesis of urothelial carcinoma (UC) remain limited. This is due to insufficient in vivo models that can accurately recapitulate the pathogenesis of UC recurrence and elucidate the involvement of the tumour microenvironment (TME) during carcinogenesis. Models of cancer pathomechanism in monolayer culture provide inaccurate resemblance due to biophysical and chemical changes. In simplified 2D culture conditions, factors such as tissue architecture, cell-to-cell and cell-to-matrix interaction, and mechanical and biochemical networks, all of which are involved in drug response, are lost. Three-dimensional (3D) culture of clinical biopsy is considered an ideal model to understand UC pathogenesis, the role of the microenvironment, and mechanical adaptations due to improved translational capacity. However, limited biopsies and challenges in primary cell culturing have shifted researchers towards developing cell line-based 3D culture in the pursuit of pathomechanism exploration. A comprehensive literature evaluation was carried out by searching the PubMed, Scopus, and Web of Science databases from January 2000 to May 2022. The initial search yielded 525 articles, and 195 studies were selected based on the inclusion and exclusion criteria. This review highlights recent challenges, future strategies, and the clinical implications of developing high-throughput, cell line-based 3D models for personalized UC treatment, a critical gap in the current literature.
Moringa seeds mitigate oxidative stress and promote antioxidant activity in aging male rats
by Hamed
N.,
Hammad
H.,
Abdou
M.
Summary: The aim of this study was to examine the antioxidant effects of one of the natural plant sources against oxidative stress caused by aging. Moringa oleifera seeds (MOS), the less utilized part, were chosen to investigate their role against oxidative stress in aging male albino rats.
Up-regulation of miR-485-3p in Iranian patients with relapsing-remitting multiple sclerosis by targeting HLADRB1
by Firouzabad
M.,
Seifati
S.
Summary: Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS). MicroRNAs (miRNAs) are tiny molecules that act as regulators within cells, influencing various processes linked to diseases like MS. Understanding the specific role of miRNAs in MS is crucial for developing new treatment strategies. This study focused on an Iranian population with relapsing-remitting MS. The researchers aimed to examine the levels of a particular miRNA, miR-485-3p, and its target gene, HLADRB1, over a minimum two-month period. By investigating these molecules, the study sought to shed light on the potential involvement of miR-485-3p in the pathogenesis of MS.
Relationship between Covid-19 pneumonia intensity with lymphopenia and CRP levels
by Panahi
M.,
Bolvardi
E.,
Disfani
H.,
Layegh
P.,
Foroughian
M.,
Hoseini
S.
Summary: COVID-19 is a highly contagious and deadly disease. However, there is no accurate diagnostic test to predict its severity. The aim of this study was to determine the relationship between the lymphocyte counts and CRP levels and the severity of pulmonary involvement shown in the CT scan of the patients with pneumonia caused by COVID-19.
Methylation of HPV-16 and HPV-18 E6 promoter CpG sites in women with abnormal pap smears
by Haddadi
S.,
Pirani
M.,
Dadbinpour
A.,
Kalantar
S.
Summary: HPV-16 and HPV-18 account for around 70% of cases of invasive cervical cancer worldwide. These are highly pathogenic and high-risk genotypes. The most prevalent sexually transmitted disease is human high-risk papillomavirus (HR-HPV), which can infect anyone who engages in sexual activity at any time in their life. To evaluate the possibility that the virus causes malignant lesions in infected women with high-risk HPV types who have normal and abnormal Pap smears, the current study examined the methylation pattern of CpG islands in the oncogene promoter of high-risk HPV E6.
Severe haemolytic disease of foetus and new born due to Rhesus D alloimmunisation in highly sensitised Rhesus D negative pregnant woman
by Hassan
M.,
Noor
N.,
Ramli
M.,
Abdullah
M.,
Iberahim
S.,
Zulkafli
Z.,
Rahman
W., S.,
Bahar
R.,
Yusoff
S.
Summary: Severe hemolytic disease of the fetus and newborn (HDFN) due to red cell alloimmunization is a frequent cause of recurrent fetal loss. This condition becomes critical when standard treatments like intrauterine transfusion (IUT) or immune-modulating therapies such as therapeutic plasma exchange (TPE) and intravenous immunoglobulin (IVIG) are unavailable or not administered in a timely manner. This case report emphasizes the potential benefits of early TPE and IVIG administration.
Safety and Efficacy of Combined Oral Misoprostol and Foley Catheter Treatment in Comparison with Oral Misoprostol Alone for Labor Induction: A Randomized Clinical Trial study
by Beyrami
S.,
Noorzadeh
M.,
Naemi
M.
Summary: In the context of a rising trend in labor induction cases, limited research has explored the efficacy of the simultaneous use of misoprostol and Foley catheter methods. This clinical trial investigates the efficacy and safety of combining these labor induction techniques compared to the use of oral misoprostol alone.
Inhibiting autophagy does not decrease drug resistance in breast cancer stem-like cells under hypoxic conditions
by Khan
B.,
Nhan
T.,
Pham
P.
Summary: Breast cancer has been one of the most frequently diagnosed cancers in women over the past decade. The presence of a breast cancer stem cell (BCSC) population within breast tumors significantly contributes to malignancy and drug resistance. Under the hypoxic conditions of breast tumors, BCSCs exhibit increased resistance to chemotherapy, complicating treatment and reducing its efficacy. Consequently, targeting BCSCs is considered a crucial strategy for breast cancer treatment. We hypothesize that the chemotherapy resistance of BCSCs is dependent on the upregulation of autophagy triggered by hypoxia. This study aims to investigate the relationship between autophagy and drug resistance of BCSCs in hypoxic conditions.
Association of stress and anxiety with Alzheimer’s: post-COVID-19 pandemic global perspective
by Khan
M.,
Ahmad
T.
Summary: Alzheimer's is a neurodegenerative disorder mainly caused by aging, diabetes, stress, depression, anxiety, hypertension, obesity, etc. This bibliometric study investigated the correlation of stress and anxiety with Alzheimer's Disease to understand recent research trends and post-COVID-19 pandemic trending topics. The Web of Science database was utilized. The analysis was performed using the R package and VOSviewer software. A total of 305 articles were characterized and analyzed. The density visualization indicates that Alzheimer's disease and oxidative stress are the most prominent terms, followed by memory, dementia, anxiety, and stress. The most productive countries were China, the United States of America, and Iran.
Mutational variants of KRAS gene versus Wild-type KRAS in the survival outcomes of Vietnamese colon cancer stage II-III
by Cuong
H.,
Loi
N.,
Ngoc
T.,
Thang
V.
Summary: Colon cancer is one of the most common cancers in Vietnam and globally. The KRAS gene (Kirsten rat sarcoma) is an oncogene showing a high mutation rate in colon cancer, affecting 30% to 40% of patients. The mutated KRAS gene, which keeps the MAPK signaling pathway permanently active, is considered a negative factor in the survival of colon cancer patients. Recently, several studies have been conducted to evaluate the specific prognoses related to distinct KRAS mutations, but the results were controversial. Mutations in different KRAS codons may impact colon cancer treatment models and prognoses. Therefore, the impacts of codon-specific KRAS mutations on survival require further clarification. This study aims to determine the associations between codon-specific KRAS mutations and survival in Vietnamese patients at stages II - III.
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Editors' quote
Phuc Van Pham, Editor-in-Chief
Affiliation
Why publish with Biomedical Research and Therapy
Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Scopus, Embase (Elsevier), Asean Citation Index, Google Scholar
Journal Metrics
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Speed (Median)
35 days to first decision for all manuscripts
55 days from submission to acceptance
15 days from acceptance to publicationCitation metrics
0.14 Journal Citation Indicator (JCI, 2023)
0.6 Journal Impact Factor (JIF, 2023)0.8 5-year Impact Factor (JIF, 2023)
Acceptance Rate
35.20%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
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Editor-in-Chief: [email protected]; [email protected]
Support Team: [email protected]; [email protected]
Managing Editor: [email protected]
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