journal description

Biomedical Research and Therapy - Vietnamese Journal for Medical Biotechnology and Medicine Incorporating Advances in Regenerative Medicine publishes 12 peer-reviewed issues annually across a broad spectrum of biomedical and clinical sciences. Distinct from many open-access journals that charge authors but offer free access to readers, Biomedical Research and Therapy does not impose fees for subscription, submission, processing, publication, or even color reproduction of images. As an internationally recognized peer-reviewed journal, it is dedicated to publishing high-quality open-access research articles. It places a particular emphasis on basic, translational, and clinical research into molecular therapeutics and cellular therapies. This includes coverage of animal models and clinical trials. The journal's peer-review process rigorously ensures that only content which is scientifically, technically, and ethically sound, and adheres to standard reporting guidelines, is accepted. The editorial policies of Biomedical Research and Therapy align with the guidelines set forth by the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE), ensuring adherence to the highest standards of publication ethics.

latest issues


2024 Journal Citation Reports: Changes in Journal Impact Factor category rankings to enhance transparency and inclusivity


We will move from edition-specific category JIF rankings to unified rankings for each of our 229 science and social science categories.

We will no longer provide separate JIF rankings for the nine subject categories that are indexed in multiple editions. For example, the Psychiatry category is included in both Science Citation Index – Expanded (SCIE)™ and Social Sciences Citation Index (SSCI)™ and we currently publish a separate Psychiatry ranking for each edition. We will replace these separate rankings with a single, unified ranking.

Additionally, the new unified rankings will include journals indexed in ESCI. Using Psychiatry once again as our example – we will display a single Psychiatry ranking that includes journals indexed in SCIE, SSCI and ESCI.

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latest articles

Case report

Antithrombin deficiency with portal vein and superior mesenteric vein thrombosis—a case report

by Saidin N., I., S., Jamallodin F., B., Hassan M., N., Iberahim S., Abdullah A., H., Zahidin M., A., Zulkafli Z., Noor N. H. M.

Summary: A deficiency in antithrombin (AT) can be hereditary or acquired. It is characterized by an AT activity level that is less than 80% of normal or the lower limit of the reference range on a regular basis. In some cases, AT deficiency has been linked to an increased risk of thromboembolism.

Original Research

microRNA-9-5p and its target nuclear factor kappa B are differentially expressed in type-2 diabetes patients

by Narayan R N., P A., P P A., S., Sekar D.

Summary: According to various studies, type II diabetes (T2D), a serious metabolic disease marked by insulin resistance with disrupted glucose homeostasis, affects millions of people worldwide and may reach 552 million cases by 2030. Recent studies highlighted the key role of microRNAs (miRNAs) in various cellular processes related to disease development. Moreover, studies have indicated increased concentrations of miR-9-5p in T2D individuals, thereby suggesting a possible role for miR-9-5p in influencing the regulation of glucose metabolism. Hence, the current study aims to focus on miR-9-5p and its target nuclear factor kappa B (NFkB1) in T2D by utilizing publicly available genome sequences to point out their potential as diagnostic and therapeutic biomarkers.

Original Research

A mixture of secretions and extractions derived from antler stem cells heal open wounds in rats with a tendency to leave no scar

by Huynh P., Cao A., Le T., Nguyen S., Vu N.

Summary: Deer antlers are remarkable organs as they can regenerate seasonally and leave no scars. Antler-derived stem cell therapy applications are of increasing interest in food, beauty, and medicine.


Unlocking Insights into Alloantibodies in Thalassemia: Findings from a Single-Center Study

by Rameli N., Othman R., Ruslan M., Akbar N., Zulkeflee R., Rohim R., A., A., Daud A., Adzahar S.

Summary: Thalassemia is a common inherited hemoglobin disorder in Malaysia. Regular transfusions of packed red cells are required to treat transfusion-dependent thalassemia. These transfusions, although lifesaving, may lead to complications such as red blood cell (RBC) alloantibody formation. This study aimed to determine the incidence of RBC alloantibodies in thalassemia patients who regularly received blood transfusions at our center.

Case report

Detection of clinically significant anti-IH antibodies in a para-Bombay patient during pregnancy

by Noor N., H., M., Ibrahim N., N., Hassan M., N., Iberahim S., Zulkafli Z., Yusoff S., M., Bahar R., Ramli M., Rahman W., S., W., A., Abdullah M., Hajar C., G., N., Assyuhada M., G., S., N., Cai X., H., Edinur H. A.

Summary: The para-Bombay blood phenotype is a rare blood group variant, with a limited number of cases reported worldwide.

Case report

Hyperleukocytosis: a unique cause of an unidentifiable hemoglobin A1c peak

by Razak A., A., A., Ismail T., S., T., Zulkeflee R., H., Rahim S., N., A., Zulkeflee H., A., Nik W. N. F. H. W.

Summary: Glycosylated hemoglobin (HbA1c) serves as a crucial biomarker for the diagnosis and monitoring of diabetes. It can be measured via different methods. Interference during analysis can potentially arise from various factors, including rare occurrences such as hyperleukocytosis.


The diagnostic value of plasma gelsolin levels in sepsis: A mini review

by Abid H., Jabbari A., Al-Tameemi H.

Summary: Sepsis remains a critical health concern with high mortality despite medical advances. Early diagnosis and risk stratification are vital to guide appropriate intervention and improve outcomes. Plasma gelsolin, an actin-binding protein that helps clear circulating filamentous actin, has emerged as a promising diagnostic and prognostic biomarker for sepsis. This review summarizes evidence on the usefulness of plasma gelsolin for these applications. Studies consistently show significantly decreased plasma gelsolin levels in septic humans and animal models compared to healthy controls. Reductions correlate with sepsis severity and development of multiorgan dysfunction. Plasma gelsolin demonstrates a potential to distinguish sepsis from non-infectious inflammation. It also aids in mortality prediction, with lower levels portending worse outcomes. One study found that sepsis non-survivors failed to recover depleted gelsolin levels over time, in contrast to survivors. The degree of gelsolin depletion is likely connected to the extent of cellular injury from sepsis, with consumption overwhelming plasma gelsolin’s actin-scavenging capacity. Resulting persistent circulation of actin filaments is posited to mediate organ damage. Though most studies are limited by small sample sizes, plasma gelsolin consistently correlates with clinical deterioration. Substantiating its prognostic utility could enable risk stratification to guide sepsis management. Demonstrating a mortality benefit of gelsolin replacement therapy could also spur the development of novel treatments. Further research on plasma gelsolin is warranted to ultimately improve outcomes of this common and deadly syndrome.

Original Research

Comparison of Celecoxib and Gabapentin in Preventing Post-Cesarean Section Pain: A Randomized Controlled Clinical Trial

by Gholami H., Rashtchi V., Arianpour F.

Summary: Given the established effectiveness of gabapentin and NSAIDs in reducing postoperative pain and the paucity of comparative studies of gabapentin and NSAIDs for postoperative pain management, our current study was designed to assess and compare the effectiveness of celecoxib and gabapentin in preventing post-cesarean section pain.

Original Research

DNA promoter methylation of cancer-associated genes in patients with head and neck squamous cell carcinoma

by Kurevlev S., Tskhovrebova L., Aghajanyan A., Gordon K., Polyakov A., Ratushny M., Fatkhudinov T.

Summary: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world. Abnormal methylation can be one reason for this cancer. This study aimed to investigate the DNA promotor methylation status of cancer-associated genes (ATM, APC, CDO1, RB1, TP53, and WIF1) in patients with HNSCC.


Hyaluronic acid, platelet-rich plasma, bone marrow aspirate concentrate, the stromal vascular fraction, or mesenchymal stem cells: which is the best candidate for treating knee osteoarthritis?

by Phuong L., T., B., Ngoc V., B., Phuc P. V.

Summary: Regenerative medicine-based therapies are considered promising for some chronic diseases, such as osteoarthritis (OA). Because OA is the most common disease in many countries, significant efforts have long been made to develop effective treatments. Current therapies for OA include hyaluronic acid, platelet-rich plasma, bone marrow aspirate concentrates, the stromal vascular fraction from adipose tissue, bone marrow-derived mesenchymal stem cells, and adipose tissue-derived mesenchymal stem cells. Clinical trials testing these agents for OA treatment have been performed for over 10 years. In this review, we summarize and compare the effects of these agents for treating knee OA based on recent meta-analyses.

Original Research

Tamoxifen-Induced Fatty Liver is Observed in New Zealand White Rabbit by Ultrasonography

by Shahriari-Ahmadi M., Masouleh M., N., Kaveh V.

Summary: Tamoxifen is a chemotherapy drug used in cancer treatment. In addition to its anticancer effect, tamoxifen also has hepatotoxic effects. This study aims to evaluate the induction effect of tamoxifen in the development of fatty liver in New Zealand white rabbits by employing ultrasonography.

Case report

Suspected case of erythema multiforme major caused by combination therapy of glimepiride, voglibose, and metformin with clomiphene citrate in a polycystic ovary syndrome and type 2 diabetes patient in India

by Kumar H., Gangwar R., Kumar A., Zargar A., Sharma A.

Summary: Research has suggested that people with polycystic ovary syndrome (PCOS) have an increased risk of developing type 2 diabetes or prediabetes before the age of 40 years. Erythema multiforme major refers to a severe generalized rash with limited desquamation and mucous membrane involvement with blister formation. This case report will help all health care professionals be aware and vigilant regarding the adverse drug reaction caused by the combination of glimepiride, voglibose, metformin, and clomiphene citrate. A female patient in her early 30s visited the outpatient department for follow-up with a history of PCOS and type 2 diabetes. Her main complaints were itching, redness, and a pink and brown skin allergy on the face, neck, shoulder, breast, abdomen, and back, along with breast tenderness or discomfort. She had been prescribed oral clomiphene citrate 100 mg, vitamin D 10,000 IU twice weekly, and calcium 1,250 mg twice daily for PCOS and a combination of glimepiride 2 mg, voglibose 0.2 mg, and metformin 500 mg SR daily for type 2 diabetes. An adverse drug reaction (ADR) was found probable based on assessment with the Naranjo scale. ADRs such as maculopapular rash following erythema multiforme major are fatal. They can cause stress and anxiety and reduce the patient's quality of life. This case will help physicians and clinicians in the early detection and management of ADRs.


PARP inhibitors in newly diagnosed or recurrent ovarian cancer maintenance therapy: evidence of efficacy and safety from randomized controlled trials

by Quynh P., N., N., Nguyen P., T., L., Nguyen H., T., Phung T., L., Nguyen D., Duong K.

Summary: This review aimed to systematically synthesize and report the clinical outcomes of poly-ADP ribose polymerase inhibitors (PARPis) for maintenance therapy among ovarian cancer (OC) patients.

Original Research

Computational and expression analysis of microRNA-149-5p and its target, interleukin-6, in chronic kidney disease

by Ahsan M., K P A., Usman P P A., S., Sekar D.

Summary: Chronic kidney disease (CKD) is an ailment marked by a reduction in the glomerular filtration rate or the presence of proteinuria. Millions of people are affected worldwide, and so far, the mechanisms underlying these effects remain mostly unknown. Recently, the role of microRNAs (miRNAs) in several cellular processes associated with the development of diseases has been discovered. Studies have suggested that miR-149-5p may play a role in renal function and kidney disorders and be linked with inflammation, fibrosis, or apoptosis within the kidneys. In addition, miR-149-5p often targets signaling pathways, including TGF-β, Wnt/β-catenin, and NF κB. Hence, this study focused on miR-149-5p and its biomarker, interleukin-6 (IL-6), as potential indicators of CK D. Computational analyses were employed for miR-149-5p identification within CKD genome sequences, revealing its potential involvement in disease processes.



Journal Collections

Covid-19 publications
The collections of Covid-19 related articles published by Biomedical Research and Therapy
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Journal Supplements

Conference Abstracts
The collections of abstract book were published by Biomedical Research and Therapy
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Journal Collections


Stem Cells and Regenerative Medicine
The collections of published articles about stem cells as well as regenerative medicine. 
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Special Issues 

Special Issues 
Biomedical Research and Therapy would like to invite guest editors to contribute special issue. 
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Journal Collections

Natural Extract
The collections of published articles about herbal, natural products. 
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Publication Awards

The best original research articles
Every year, all authors published their studies as Original research in Biomedical Research and Therapy can join this awards.
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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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